FIGURE 5.

Structural comparison of the polymerase:Pt-GG·dCTP complexes. A, structure of Dpo4 in complex with the Pt-GG-containing DNA. The finger domain and the polymerase-associated domain (PAD) are shown. The distance between N2(5′-dG) and N2(3′-dG) of the Pt-GG lesion is indicated. B, structure of human polη in complex with the Pt-GG DNA. C, structure of polβ in complex with the Pt-GG DNA in the presence of the active site Mn²⁺. The α-helix N that interacts with the replicating base pair is shown.