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. 2014 Sep 24;289(45):31397–31410. doi: 10.1074/jbc.M114.576819

FIGURE 1.

FIGURE 1.

A combination of curcumin with either gA or ouabain selectively kills cells with ABCG2-induced MDR phenotype. A, sensitivity of parental (HEK-293 control) cells (black) and HEK-ABCG2 cells (red) to gA in the absence (solid curves) or presence (dashed curves) of 2 μm curcumin. B, sensitivity of HEK-293 control (black) and HEK-ABCG2 cells (red) to ouabain in the absence (solid curves) or presence (dashed curves) of 2 μm curcumin. C and D, fluorescence-based life versus death assay of HEK-293 control (top panels) and HEK-ABCG2 cells (bottom panels) after 72 h of incubation with the specified compound(s).