TABLE 2.

Mean fluorescence intensity (MFI) and percentage of efflux of Bp in HEK-ABCG2 cells treated with the specified compound(s)

Distribution	Treatment	MFIa	Effluxb
			%
1	250 nm Bp (substrate)	105 ± 66	100
2	Bp + 10 μm FTC (inhibitor)	546 ± 4	0
3	Bp + 2 μm curcumin	139 ± 60	92 ± 19
4	Bp + 35 nm gA	108 ± 71	99 ± 21
5	Bp + 35 nm gA + 2 μm curcumin	540 ± 2	1.3 ± 1
6	Bp + 7.5 nm ouabain	106 ± 42	100 ± 19
7	Bp + 7.5 nm ouabain + 2 μm curcumin	376 ± 32	38 ± 12

^a Mean values of the mode (i.e. the most frequently measured fluorescence intensity) of each distribution ± standard deviation of the mean from two independent experiments.

^b The difference in MFI values in the presence of 250 nm Bp alone to that in the presence of 250 nm Bp with 10 μm FTC was defined as 100% efflux activity.