FIGURE 9.
Schematic diagram indicating a hypothesis of the mechanism of GnT-V expression regulating colon tumor development. Pathways implicated in the regulation of colon tumor development are depicted based on the observations presented in this study. The expression level of GnT-V regulates the canonical Wnt/β-catenin signaling pathway through N-glycan modulation of Wnt receptors, resulting in abnormal colon tumorigenesis and affecting adenoma progression in Apcmin/+ mice. The regulation of colon tumor development by GnT-V is mediated at least in part by alterations in the cancer stem cell population.