Table 1.
Clinical and Pathological Characteristics of Patients With FVPTCs
| All Patients (n = 126) |
BRAF Status |
RAS Status |
|||||
|---|---|---|---|---|---|---|---|
| Negative (n = 89) | Positive (n = 37) | P | Negative (n = 81) | Positive (n = 45) | P | ||
| Demographics | |||||||
| Age, y, mean ± SD | 49 ± 16 | 47 ± 16 | 54 ± 13 | .04 | 51 ± 17 | 45 ± 13 | .04 |
| Female, n (%) | 101 (80) | 70 (79) | 31 (84) | .62 | 66 (81) | 35 (78) | .65 |
| Radiation exposure, n (%) | 5 (4) | 4 (5) | 1 (3) | .62 | 4 (5) | 1 (2) | .66 |
| Family history, n (%) | 5 (4) | 2 (2) | 3 (8) | .16 | 4 (5) | 1 (2) | .66 |
| Primary tumor characteristics | |||||||
| Tumor diameter, cm, median (IQR) | 2.0 (1.6) | 2.1 (1.5) | 1.6 (1.5) | .13 | 1.8 (1.7) | 2.1 (1.5) | .67 |
| Multifocality, n (%) | 31 (25) | 23 (26) | 8 (22) | .65 | 19 (23) | 12 (27) | .83 |
| LVI, n (%) | 14 (11) | 8 (9) | 6 (16) | .35 | 12 (15) | 2 (4) | .08 |
| Encapsulated, n (%) | 40 (32) | 35 (40) | 5 (14) | <.01 | 23 (29) | 17 (38) | .32 |
| Capsular invasion, n (%) | 5 (4) | 5 (6) | 0 (0) | .32 | 4 (5) | 1 (2) | .65 |
| Vascular invasion, n (%) | 3 (2) | 3 (3) | 0 (0) | .55 | 2 (3) | 1 (2) | .92 |
| Extrathyroidal extension, n (%) | 1 (1) | 0 (0) | 1 (6) | .23 | 1 (2) | 0 (0) | .40 |
| Microscopic ETE, n (%) | 2 (2) | 1 (2) | 0 (0) | .58 | 1 (2) | 0 (0) | .40 |
| Incomplete resection, n (%) | 7 (6) | 5 (6) | 2 (6) | .97 | 5 (6) | 2 (5) | .71 |
| Cervical LN status | |||||||
| Central LN+, n (%) | 9 (7) | 9 (9) | 0 (0) | .60 | 6 (8) | 3 (7) | .42 |
| Lateral LN+, n (%) | 4 (3) | 4 (5) | 0 (0) | .63 | 2 (3) | 2 (4) | .65 |
| PTmicroC, n (%) | 34 (27) | 24 (27) | 10 (27) | .99 | 23 (28) | 11 (24) | .68 |
| AJCC TNM stage | |||||||
| I, n (%) | 117 (94) | 83 (94) | 34 (92) | .59 | 73 (91) | 44 (98) | .52 |
| II, n (%) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | ||
| III, n (%) | 7 (6) | 4 (5) | 3 (8) | 6 (8) | 1 (2) | ||
| IV, n (%) | 1 (1) | 1 (1) | 0 (0) | 1 (1) | 0 (0) | ||
| MACIS score, mean ± SD | 4.9 ± 1.0 | 4.9 ± 1.1 | 5.1 ± 1.2 | .23 | 5.1 ± 1.2 | 4.7 ± 1.0 | .05 |
Abbreviations: ETE, extrathyroidal extension; IQR, interquartile range; LN, lymph node; LVI, lymphovascular invasion; PTmicroC, Papillary thyroid microcarcinoma; TNM, tumor, node, metastasis. There were no tumors with T4a/b extrathyroidal extension or extranodal extension.