Table 1.

Expressions of Three Hereditary States With Uncoupling of Secretion From Size in the Hormone Secretory Tissues

Syndrome	Earliest Onset, y	Main Expression	Other Expression	Hormone in Excess	Histology of Hormone-Secreting Tissue
Familial hypocalciuric hypercalcemia	0	High serum calcium	Relative hypocalciuria	PTH	Normal; few with mild hyperplasia
Congenital diazoxide-resistant hyperinsulinism	0	Low serum glucose	Macrosomia	Insulin	Some β-cell nuclei enlarged without β-cell hyperplasia
Congenital hyperaldosteronism type III (with germline KCNJ5 G151E)	0	Hypertension	Low serum potassium	Aldosterone	CAT scans normal in each of 6 carriers. Histology normal in 1 case

Abbreviation: CAT, computerized axial tomography.