Table 2.

GO Enrichment Analysis of Genes in 2 Final Candidate Modules

GO Term	Biological Process	Overlapped Genes	P Valuea	Adjusted P Valueb
GO:0061053	Somite development	SMAD3, WNT1, SFRP1, WNT4, SFRP2, DKK1	7.43 × 10−11	1.99 × 10−8
GO:0016055	Wnt receptor signaling pathway	SMAD3, WNT1, SFRP1, SFRP2, LRP5, MDFI, WNT4, DKK1	3.53 × 10−10	9.46 × 10−8
GO:0003002	Regionalization	SMAD3, WNT1, SFRP1, SFRP2, LRP5, MDFI, WNT4, DKK1	4.02 × 10−10	1.08 × 10−7
GO:0060070	Canonical Wnt receptor signaling pathway	SMAD3, WNT1, SFRP2, LRP5, MDFI, WNT4, DKK1	4.11 × 10−10	1.10 × 10−7
GO:0030111	Regulation of Wnt receptor signaling pathway	SMAD3, SFRP1, SFRP2, LRP5, MDFI, WNT4, DKK1	4.44 × 10−10	1.19 × 10−7
GO:0009952	Anterior/posterior pattern specification	SMAD3, WNT1, SFRP1, LRP5, WNT4, SFRP2, DKK1	1.09 × 10−9	2.92 × 10−7
GO:0009887	Organ morphogenesis	SMAD3, ESR1, TNFRSF1B, SFRP1, SFRP2, LRP5, MDFI, WNT1, WNT4, DKK1	1.37 × 10−9	3.67 × 10−7
GO:0060828	Regulation of canonical Wnt receptor signaling pathway	SMAD3, SFRP1, SFRP2, LRP5, WNT4, DKK1	2.70 × 10−9	7.24 × 10−7
GO:0060562	Epithelial tube morphogenesis	SMAD3, SFRP1, SFRP2, LRP5, WNT4, WNT1, ESR1	2.96 × 10−9	7.93 × 10−7
GO:0001649	Osteoblast differentiation	SMAD3, SFRP1, SFRP2, LRP5, WNT4, ESR1	4.68 × 10−9	1.25 × 10−6

^aHypergeometric test P value.

^bBonferroni correction-adjusted P value.