Fig. 2.

Receptor tyrosine kinases as a highly regulated class of proteins in metastatic pancreatic cancer revealed by quantitative proteomics analysis. A, proteomes of liver metastasis and lung metastasis were found to be more similar to each other than to that of peritoneum metastasis. This result is consistent with genetic data from in our previous study showing that lung pancreatic metastasis is evolutionarily closer to liver pancreatic metastasis. This indicates that a pattern of proteome expression among genetically close clones is closely related. In other words, a genetically different clone may have a different proteome expression. B, the pie chart shows that ∼42% of proteomes in cells derived from distal metastatic pancreatic cancers were categorized in proteins that were highly variable when pairwise comparison of three metastases was carried out. C, bioinformatics analysis showed that receptor/signal transducer activities were enriched in altered proteome.