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. 2014 Aug 6;13(11):2883–2895. doi: 10.1074/mcp.M114.038224

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© 2014 by The American Society for Biochemistry and Molecular Biology, Inc.

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Fig. 5. — The NuA3 HAT complex has two functionally distinct forms that participate in transcription. A, Model of the NuA3a HAT complex. Yng1 binds to H3K4me3 through its PHD finger, thereby recruiting NuA3a to the promoter regions of actively transcribed genes. Sas3 then acetylates H3K14, leading to transcription initiation at a subset of genes (19, 24–27). B, Model of the NuA3b HAT complex. NuA3b contains a unique member, Pdp3. Pdp3 binds to H3K36me3 through its PWWP domain, thereby recruiting NuA3b to the coding regions of actively transcribed genes. Although the function of NuA3b is not fully defined, we speculate that Sas3 may acetylate histones or nonhistone proteins to facilitate transcription elongation.