Fig. 6.
The potential ArfGAP1 lipid packing sensor (ALPS) motifs. Each of the potential ALPS motifs and sequences for HsNup133 (A), VpNup133 (B), ScNup133 (C), and ScNup120 (D, E) is presented. The potential ALPS motifs (red) were visualized in their corresponding structures (gray) using UCSF Chimera (37) and are highlighted by blue circles. The helical-wheel representations of the potential ALPS motifs are also shown, with an arrow in the center of the helical-wheel representing the direction and strength of the mean hydrophobic moment of the corresponding ALPS motif.