Fig. 5.

SAHA gene and disease network linkages. A, protein–disease connectivity map. Each column represents a disease, and each row represents a protein involved in one of the diseases. The numbers inside the matrix correspond to the number of disease subtype (for example, multiple types of cancer). Light orange corresponds to the group of proteins that have a connectivity weight of 1 or 2, and dark red corresponds to the group of proteins involved in multiple diseases with many subtypes and thereby having larger weight numbers. B, Sin3 disease network. Each node represents a disease, and two diseases are connected to each other if they share at least two proteins that are associated with both diseases. The size of the circle is proportional to the total number of links.