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A, Cell cytotoxicity assays. Percentage of viable A2780-DR and A2780 cells treated with cisplatin at different concentrations for 24 h determined by using CCK-8 assay. Results are expressed as the mean of three experiments with p value <0.001; B, accumulation of cisplatin in 10 μm cisplatin treated A2780 and A2780-DR cells for 24 h as determined by electrospray ionization mass spectrometry. *** p < 0.001.
