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. 2014 Jul 21;14:522. doi: 10.1186/1471-2407-14-522

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Copyright © 2014 Wehrhan et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Macrophage polarization in the lymph node sinus depending on the Pn-status of the primary tumor. a) The figure shows the ratio between the CD11c cell count and the CD68 cell count in the lymph node sinus (LN sinus) as indicator of M1 polarization. Tumor draining lymph nodes free of metastasis have been examined. P-values generated by the ANOVA-test are indicated. A significantly decreased CD11c/CD68 ratio in the lymph node sinus can be found in cases with perineural infiltration at the primary tumor site (Pn1) compared to Pn0 cases. b) The figure shows the ratio between the CD163 cell count and the CD11c cell count in the lymph node sinus (LN sinus) as indicator of M2 polarization. Tumor draining lymph nodes free of metastasis have been examined. P-values generated by the ANOVA-test are indicated. A significantly increased CD163/CD11c ratio in the lymph node sinus can be found in cases with perineural infiltration at the primary tumor site (Pn1) compared to Pn0 cases. c) The figure shows the ratio between the MRC1 cell count and the CD11c cell count in the lymph node sinus (LN sinus) as indicator of M2 polarization. Tumor draining lymph nodes free of metastasis have been examined. P-values generated by the ANOVA-test are indicated. A significantly increased MRC1/CD11c ratio in the lymph node sinus can be found in in cases with perineural infiltration at the primary tumor site (Pn1) compared to Pn0 cases.