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. 2014 Jul 15;14:391. doi: 10.1186/1471-2334-14-391

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Copyright © 2014 Campi-Azevedo et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Snapshot of immunological and virological biomarkers following 17DD-YF primary vaccination with different doses (27,476 IU-current; 10,447 IU; 3,013 IU; 587 IU; 158 IU and 31 IU). (A) Selection of biomarkers with equivalent kinetics timeline with viremia and PRNT [Viremia (); PRNT (); IL-8/CXCL-8 (); MCP-1/CCL-2 (); MIG/CXCL-9 (); IP-10/CXCL-10 (); TNF (), IFN-γ () and IL-2 ();IL-4 (), IL-5 () and IL-10 ()]. (B) Overlay graphs highlighting that IFN-γ and IL-10 are relevant complementary biomarkers associated with the viremia kinetics. Results are expressed as the global maximum values of each timepoint to baseline (viremia, , range 0 to 1.6E + 04 copies/mL; INF-γ, , range 0 to 4 baseline fold; IL-10, , range 0 to 2 baseline fold).

Inline graphic — Snapshot of immunological and virological biomarkers following 17DD-YF primary vaccination with different doses (27,476 IU-current; 10,447 IU; 3,013 IU; 587 IU; 158 IU and 31 IU). (A) Selection of biomarkers with equivalent kinetics timeline with viremia and PRNT [Viremia (); PRNT (); IL-8/CXCL-8 (); MCP-1/CCL-2 (); MIG/CXCL-9 (); IP-10/CXCL-10 (); TNF (), IFN-γ () and IL-2 ();IL-4 (), IL-5 () and IL-10 ()]. (B) Overlay graphs highlighting that IFN-γ and IL-10 are relevant complementary biomarkers associated with the viremia kinetics. Results are expressed as the global maximum values of each timepoint to baseline (viremia, , range 0 to 1.6E + 04 copies/mL; INF-γ, , range 0 to 4 baseline fold; IL-10, , range 0 to 2 baseline fold).