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. 2014 Jul 15;7:51. doi: 10.1186/s13045-014-0051-y

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Copyright © 2014 Bartram et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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BCL11b expression in the stages of normal T-cell development. In the murine model BCL11b expression begins during the transition of DN1 to DN2 and continues throughout further differentiation steps and in mature T-cells [[39]]. Knockout at DN2 stage leads to a NK like phenotype with differentiation arrest and a high proliferative potential [[13]]. The corresponding human T-ALL immunophenotypes are indicated. DN = Double Negative, DP = Double Positive, NK = Natural Killer cells, ETP = Early T-cell progenitors, ▲up-regulation, ▼down-regulation.