Table 1.
Clinical characteristics of GMALL T-ALL patients with respect to BCL11b expression
|
Characteristics |
BCL11b
-low |
BCL11b-
high |
|
|---|---|---|---|
| Q1 | Q2-4 | P-value | |
| n |
40 |
129 |
|
|
BCL11b expression |
|
|
|
| Median |
0.1 |
0.8 |
|
| Range |
0-0.2 |
0.2-12.3 |
|
| Age |
|
|
n.s. |
| 15-35 yrs |
27 |
70 |
|
| 36-55 yrs |
13 |
48 |
|
| 56-65 yrs |
0 |
11 |
|
| Sex |
|
|
n.s. |
| Female % |
20% |
26% |
|
| WBC, × 109/l |
|
0.01 |
|
| <30,000 |
24 |
42 |
|
| 30-100,000 |
10 |
53 |
|
| >100,000 |
5 |
30 |
|
| T-ALL subtype |
|
0.01 |
|
| Early n (%) |
17 (42%) |
23 (18%) |
|
| Mature n (%) |
5 (13%) |
22 (17%) |
|
| Thymic n (%) |
18 (45%) |
84 (65%) |
|
| Response to induction therapy |
n.s. |
||
| CR n (%) |
37 (95%) |
115 (94%) |
|
| ED n (%) |
1 (3%) |
3 (2%) |
|
| Failure n (%) | 1 (3%) | 5 (4%) | |
Abbreviations: CR = complete remission, ED = early death, WBC = white blood cell count.