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. Author manuscript; available in PMC: 2015 Oct 27.
Published in final edited form as: Dev Cell. 2014 Oct 16;31(2):248–256. doi: 10.1016/j.devcel.2014.08.018

Figure 4. Gpr124-/- CNS angiogenesis defects can be rescued by artificially activating canonical Wnt signaling in ECs.

Figure 4

(A-F) E13.5 embryos. The horizontal white line in A (column 1) shows the plane of section. Regions within the rectangles in the third column are enlarged in the fourth and fifth columns.

(G) Quantification of vascular density in the cerebral cortex at E13.5.

(H) Summary of interacting ligand, receptor, co-receptor, and co-activator combinations for canonical Wnt signaling in CNS vascular development and barrier integrity. In the retina, Lrp6 plays a minor role, and it is therefore shown in parentheses. In the brain, it is not known whether Tspan12 participates in Norrin/Fz4 signaling, and it is therefore shown in parentheses. Unknown Wnts and Frizzleds are indicated by ‘WntX’ and ‘FzX’, respectively. Hypothesized co-activators are represented by ‘X?’. Scale bars: columns 2 and 3, 500 μm; columns 4 and 5, 200 μm. See also Figure S3 and Table S2.