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. Author manuscript; available in PMC: 2015 Oct 22.
Published in final edited form as: Neuron. 2014 Oct 22;84(2):275–291. doi: 10.1016/j.neuron.2014.09.034

Figure 2. The mTOR Signaling Pathway.

Figure 2

The mTOR complexes integrate signals from nutrients, growth factors, cytokines, and various intracellular influences to elicit a variety of crucial cellular responses. While there are thousands of mTOR substrates, those that have been best characterized in the regulation of crucial cellular processes such as protein synthesis and autophagy are depicted. Abbreviations not found in text include: RTKs = receptor tyrosine kinases; TrkB = tyrosine receptor kinase B, the receptor for BDNF (brain-derived neurotrophic factor); mGluRs = metabotropic glutamate receptors; NMDA-R = N-methyl-D-aspartate receptor; PGC-1α (Peroxisome proliferator-activated receptor gamma coactivator 1-alpha).