Figure 1.

The Six2+ Cap Mesenchyme and Foxd1+ Cortical Stroma Give Rise to Distinct Cellular Lineages of the Kidney

β-gal-stained (blue) kidneys from Six2^TGC/+; R26R^lacZ/+ (A, C, and E), and Foxd1^GC/+; R26R^lacZ/+ (B, D, and F) embryos at 14.5 dpc counterstained with eosin (pink).

(A and B) Whole kidney.

(C–F) Higher magnification of the nephrogenic zone (C and D) and renal cortex with glomeruli (E and F).

a, adrenal gland; cd, collecting duct; ci, renal cortical interstitium; cm, cap mesenchyme; cs, cortical stroma; k, kidney; mi, renal medullary interstitium; ms, mesangium; nt, nephron tubule; pe, parietal epithelium; rv, renal vesicle; sb, S-shaped body; ue, ureter epithelium; um, ureter mesenchyme; ut, ureteric tip; ve, visceral epithelium (podocyte). Scale bars, 200 μm (A and B) and 50 μm (C–F).