Skip to main content
PMC home page
Infection and Immunity logoLink to Infection and Immunity
. 1972 Mar;5(3):332–336. doi: 10.1128/iai.5.3.332-336.1972

Influence of Gonadectomy on Candida albicans Urinary Tract Infection in CFW Mice

David Rifkind 1, Janet A Frey 1
PMCID: PMC422370  PMID: 4564561

Abstract

Candida albicans appeared in the urine of approximately 80% of CFW mice of both sexes within 2 weeks after intraperitoneal inoculation. During a follow-up period of 10 weeks, candiduria tended to clear, but persisted in 37% of males as compared to only 16% in females. Autopsy kidney cultures yielded candida in 53% of males as compared to 25% of females. Urine cultures in both sexes when positive contained 103.5 to 104.5 candida/ml regardless of the outcome of the infection. Preinoculation gonadectomy in both sexes increased resistance to the infection but did not alter the quantitative aspects of candiduria.

Full text

PDF
333

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ANDRIOLE V. T., COHN G. L. THE EFFECT OF DIETHYLSTILBESTROL ON THE SUSCEPTIBILITY OF RATS TO HEMATOGENOUS PYELONEPHRITIS. J Clin Invest. 1964 Jun;43:1136–1145. doi: 10.1172/JCI104998. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Abul-Fadl Y., Scott R. B. Effect of estrogen and progesterone on leukocyte glycogen and alkaline phosphatase in dogs. Proc Soc Exp Biol Med. 1969 Oct;132(1):193–194. doi: 10.3181/00379727-132-34178. [DOI] [PubMed] [Google Scholar]
  3. Caren L. D., Rosenberg L. T. Steroids and serum complement in mice: influence of hydrocortisone, diethylstilbestrol, and testosterone. Science. 1966 May 6;152(3723):782–783. doi: 10.1126/science.152.3723.782. [DOI] [PubMed] [Google Scholar]
  4. Churchill W. H., Jr, Weintraub R. M., Borsos T., Rapp H. J. Mouse complement: the effect of sex hormones and castration on two of the late-acting components. J Exp Med. 1967 Apr 1;125(4):657–672. doi: 10.1084/jem.125.4.657. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Giron D. J., Allen P. T. Effect of Estrogen and Other Steroids on MM Virus Infection in Mice. Infect Immun. 1970 Oct;2(4):426–430. doi: 10.1128/iai.2.4.426-430.1970. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. KAPPAS A., JONES H. E., ROITT I. M. Effects of steroid sex hormones on immunological phenomena. Nature. 1963 Jun 1;198:902–902. doi: 10.1038/198902a0. [DOI] [PubMed] [Google Scholar]
  7. Nicol T., Vernon-Roberts B., Quantock D. C. The influence of various hormones on the reticulo-endothelial system: endocrine control of body defense. J Endocrinol. 1965 Nov;33(3):365–383. doi: 10.1677/joe.0.0330365. [DOI] [PubMed] [Google Scholar]
  8. Schlegel R. J., Bellanti J. A. Increased susceptibility of males to infection. Lancet. 1969 Oct 18;2(7625):826–827. doi: 10.1016/s0140-6736(69)92278-8. [DOI] [PubMed] [Google Scholar]
  9. Toivanen P. Enhancement of staphylococcal infection in mice by estrogens. I. Effect of the timing, quantity and quality of the hormone. Ann Med Exp Biol Fenn. 1967;45(2):138–146. [PubMed] [Google Scholar]
  10. Toivanen P. Enhancement of staphylococcal infection in mice by estrogens. II. Effect of the inoculum size and the strain variation of bacteria and mice. Ann Med Exp Biol Fenn. 1967;45(2):147–151. [PubMed] [Google Scholar]
  11. WASHBURN T. C., MEDEARIS D. N., Jr, CHILDS B. SEX DIFFERENCES IN SUSCEPTIBILITY TO INFECTIONS. Pediatrics. 1965 Jan;35:57–64. [PubMed] [Google Scholar]

Articles from Infection and Immunity are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES