Table 3.
VEGF genotype in sporadic colorectal cancer patients stratified according to clinical characteristics
| Clinical characteristics | Number of patients (%) | C936T VEGF polymorphism | ||
|---|---|---|---|---|
| CC (%) | CT + TT (%) | P value | ||
| Mean age at diagnosis | 261 | 64.9 | 65.8 | |
| Ethnic origin | 261 | |||
| Caucasian | 219 (84,9) | 173 (66,3) | 46 (17,6) | 0.4693 |
| African-American | 42 (16,1) | 33 (12,6) | 9 (3,4) | |
| Metastasis | 261 | 0.7843 | ||
| No | 211 (80,8) | 166 (63,6) | 45 (17,2) | |
| Yes | 50 (19,2) | 40 (15,3) | 10 (3,8) | |
| Survival | 0.2619 | |||
| ≥ 5 years | 147 | 112 (76,2) | 35 (23,8) | |
| Regional lymph node | 165 | |||
| N+ | 80 (48,5) | 64 (38,8) | 16 (9,7) | 0.8485 |
| N0 | 85 (51,5) | 69 (41,8) | 16 (9,7) | |
| Infiltration | 165 | |||
| Tis-T2 | 39 (23,6) | 31 (18,8) | 8 (4,8) | 0.9408 |
| T3-T4 | 126 (76,4) | 102 (61,8) | 24 (14,5) | |
| Tumor location | 260 | |||
| Rectum | 137 (52,7) | 106 (41,1) | 29 (11,2) | 0.3116 |
| Left Colon | 79 (30,4) | 60 (23,3) | 19 (7,4) | |
| Right Colon | 44 (16,9) | 39 (15,1) | 5 (1,9) | |
| TNM | 226 | 0.6045 | ||
| I + II | 139 (61,5) | 109 (48,2) | 30 (13,3) | |
| III + IV | 87 (38,5) | 69 (30,5) | 18 (8) | |