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. Author manuscript; available in PMC: 2015 Oct 23.
Published in final edited form as: Cell Rep. 2014 Oct 16;9(2):591–604. doi: 10.1016/j.celrep.2014.09.032

Figure 6. Role of monocytes and macrophages in the resolution of STIA.

Figure 6

A. Depletion of monocytes does not affect resolution of STIA (n = 4). B. Depletion of monocytes and tissue macrophages during the resolution phase of STIA delays resolution of arthritis (n = 7). C. Repeated administration of DT depletes tissue macrophages. D. Repeated administration of DT depletes tissue macrophages: Immunohistochemistry was performed on ankle section for F4/80. JC – joint cavity, SL – synovial lining. Scale bar 50 μm. E. Depletion of tissue macrophages during resolution phase results in higher histopathological scores. Data are represented as mean ± SEM. Differences between groups were compared using two-way ANOVA for repeated measurements, with Bonferroni post-test (arthritis), or with Student’s t-test (histopathology), * p<0.05, ** p <0.01, *** p<0.001.