Table 4.
mRNA Expression Levels of Iron-Related Genes in Multiple Sclerosis Compared to Control White Matter
| Gene Symbol | Fold Changes Compared to Controls | Gene Name | Synonyms | Gene Function | Accession Number | ||
|---|---|---|---|---|---|---|---|
| PPWM | Initial Lesion | Active Lesion | |||||
| FTHa | 1.45 | 6.04 | 1.41 | Ferritin, heavy polypeptide 1 | Intracellular iron storage | NM_002032 | |
| FTL | 5.02 | 3.34 | 3.47 | Ferritin, light polypeptide | Intracellular iron storage | NM_000146 | |
| FTMT | 1.93 | 2.76 | 2.44 | Ferritin, mitochondrial | Mitochondrial iron storage | NM_177478 | |
| TF | 0.40 | 1.17 | 0.15 | Transferrin | Iron transport within cells | NM_001063 | |
| TFRC | 2.01 | 0.90 | 1.41 | Transferrin receptor | Import of transferrin-bound iron | NM_003234 | |
| SCARA5 | 0.73 | 1.74 | 2.39 | Scavenger receptor class A, member 5 | Import of ferritin-bound iron | NM_173833 | |
| SLC11A2 | 3.20 | 0.54 | 1.02 | Solute carrier family 11, member 2 | DMT1, NRAMP2 | Iron importer | NM_000617 |
| SLC11A1 | 0.48 | 0.56 | 0.73 | Solute carrier family 11, member 1 | NRAMP1 | Lysosomal iron transporter | NM_000578 |
| SLC39A14a | 2.33 | 1.75 | 0.99 | Solute carrier family 39, member 14 | ZIP14 | Iron importer | NM_015359 |
| TRPC6a | 1.93 | 5.96 | 1.21 | Transient receptor potential cation channel, subfamily C, member 6 | Iron importer | NM_004621 | |
| MCOLN1 | 1.17 | 0.56 | 0.38 | Mucolipin 1 | TRPML1 | Endosomal/lysosomal iron transporter | NM_020533 |
| CYBRD1 | 0.38 | 0.52 | 0.61 | Cytochrome b reductase 1 | DCYTB | Ferrireductase | NM_024843 |
| STEAP3 | 1.56 | 1.96 | 0.80 | STEAP family member 3 | Ferrireductase | NM_182915 | |
| SLC40A1a | 0.97 | 0.99 | 1.05 | Solute carrier family 40, member 1 | Ferroportin | Iron exporter | NM_014585 |
| CPa | 1.05 | 1.16 | 0.99 | Ceruloplasmin | Ferroxidase | NM_000096 | |
| HEPH | 3.65 | 1.88 | 3.39 | Hephaestin | Ferroxidase | NM_014799 | |
| APP | 2.16 | 1.74 | 1.92 | Amyloid beta precursor protein | Ferroxidase | NM_000484 | |
| HAMP | 1.52 | 1.04 | 0.78 | Hepcidin | Regulation of ferroportin localization | NM_021175 | |
| MON1A | 0.85 | 0.52 | 0.84 | MON1 homolog A | Regulation of ferroportin localization | NM_032355 | |
| SLC25A28 | 0.53 | 0.66 | 0.72 | Solute carrier family 25, member 28 | Mitoferrin-2 | Mitochondrial iron transporter | NM_031212 |
| FXNa | 0.94 | 0.08 | 0.56 | Frataxin | Mitochondrial iron metabolism | NM_181425 | |
a
False-negative results cannot be ruled out due to position of probes.
PPWM = periplaque white matter.