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. 2013 Sep 17;1(1):15. doi: 10.1186/2049-9256-1-15

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© Dwyer et al.; licensee BioMed Central Ltd. 2013

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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LY341495 produces a rapid antidepressant effect. (A) LY341495 produced a trend toward a reversal of stress-induced decreased sucrose preference at 24 hrs post-LY341495 treatment (not significant). (B) LY341495 reversed the stress-induced decrease in sucrose preference 48 hrs after a single treatment, indicating a rapid antidepressant effect. *P < 0.01 compared to No Stress/Vehicle; †P < 0.01 compared to Stress/Vehicle group; Stress x LY341495 interaction P = 0.05 (two-way ANOVA; LSD post-hoc tests).