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. 2014 Aug 7;2:90. doi: 10.1186/s40478-014-0090-1

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© Doorn et al.; licensee BioMed Central Ltd. 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Quantification of α-synuclein pathology in the hippocampus (HC) of control subjects, iLBD cases and PD patients. (a) Significant differences were present in α-synuclein deposits between all pyramidal subregions of the HC in the PD patients (*p < 0.05). The CA2 region was affected the most relative to the other hippocampal subregions (^#p < 0.01). (b) Comparison of α-synuclein pathology in CA2 between the three patient cohorts showed a significant increase in the PD patients compared to control and iLBD cases (*p < 0.01 vs iLBD, Ctr). Data represent mean ± SEM.