Table 1.
DNA Damage at 24 Hours Postirradiation
| Drugs | Cells | Dose (kBq/mL) | Tail length median (μm) | Olive tail distance | Comet tail DNA (%) | Rate of cell tailing (%) |
|---|---|---|---|---|---|---|
| 125I-UdR | HL-7702 | 0 | 5 | 0.51±0.10 | 1.37±0.01 | 3 |
| 37 | 3 | 0.66±0.26 | 0.93±0.18 | 20 | ||
| HepG2 | 0 | 5 | 0.49±0.23 | 1.27±0.94 | 4 | |
| 37 | 3 | 0.70±0.32 | 0.95±0.45 | 22 | ||
| 125I-UdR-CS-DLN | HL-7702 | 0 | 5 | 0.52±0.38 | 1.37±0.01 | 3 |
| 37 | 3 | 2.07±1.34a | 7.08±5.40a | 28a | ||
| HepG2 | 0 | 5 | 0.50±0.25 | 1.36±0.49 | 4 | |
| 37 | 17a,b | 8.37±5.51a,b | 24.23±10.2a,b | 56a,b |
a
p<0.05 when compared with the same cell lines treated by 125I-UdR.
b
p<0.05 when compared with HL-7702 cells treated by the same drugs.
125
I-UdR, 125I-labeled 5-iodo-2′-deoxyuridine; 125I-UdR-CS-DLN, 125I-labeled 5-iodo-2′-deoxyuridine-chitosan drug loading nanoparticles; HepG2, hepatocellular carcinoma cell line; HL-7702, normal human liver cell line.