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. 2014 Dec 1;21(16):2208–2230. doi: 10.1089/ars.2014.5845

FIG. 4.

FIG. 4.

Hypoxia treatment markedly increases β-amyloid burden in the aging APP/PS1 mouse brain. Levels of mouse soluble Aβ1-40 (A) and Aβ1-42 (B) were determined by ELISA in the APP/PS1 transgenic (Tg) and age-matched WT C57BL/6 mouse brain. Two-way ANOVA were performed, n=6–8 in each group. Data are represented as mean±SEM. (C–F) Quantification shows human soluble Aβ1-40, Aβ1-42, insoluble Aβ1-40, and Aβ1-42 contents in the Tg mouse brain. (G) The ratio of human soluble Aβ42 to Aβ40 in the Tg mice brain. (H) Human insoluble Aβ42/40 peptide ratios in the brain of Tg mice. (I, J) Quantification shows the Aβ plaque number and area in the cortex and hippocampus of the Tg mouse brain. Five brain sections per mouse were examined. **p<0.01 versus Tg group by Student's t-test, n=6–8 in each group. Data are represented as mean±SEM.