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Representative images of Aβ plaques in APP/PS1 and age-matched C57BL/6 mice brain. Aβ plaques were examined with anti-Aβ antibody. Aβ-positive plaques were significantly detectable in the cortex and hippocampus of APP/PS1 transgenic (Tg) mice brain at 8- and 14 months of age, especially in the group that underwent hypoxia treatment. There was no Aβ-positive plaque in the age-matched WT C57BL/6 mice brain. Scale Bar=200 μm.
