FIG. 6.

Hypoxia significantly reduces the expression of CD36 and Aβ-degrading enzymes in the aged mouse brain. (A) Relative expression of CD36 mRNA was normalized to β-actin in CD11b⁺ cells from the brains of APP/PS1 transgenic (Tg) and age-matched WT C57BL/6 mice. (B–D) The mRNA expression of Aβ-degrading enzymes, insulin degradation enzyme (IDE), neprilysin (NEP), and matrix metalloproteinase-9 (MMP-9) in CD11b⁺ cells from Tg and WT brains was assessed by real-time PCR. **p<0.01 versus WT group, ^##p<0.01 versus Tg group, and ^$$p<0.01 versus WT+Hypo group by two-way ANOVA, n=6–8 in each group. Values represent the mean±SEM.