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. 2014 Dec 1;21(16):2208–2230. doi: 10.1089/ars.2014.5845

FIG. 8.

FIG. 8.

Chronic hypoxia treatment attenuates NRF2-ARE signals in the aging mouse brain. (A) Representative Western blot images of the NRF2-ARE-driven antioxidants protein, heme oxygenase-1 (HO-1), nicotinamide adenine dinucleotide phosphate quinone oxidoreductase-1 (NQO1), catalytic subunits of γ-glutamyl cysteine ligase (γGCL-C) and modulatory subunits of γ-glutamyl cysteine ligase (γGCL-M) compared with GAPDH in the brains of APP/PS1 transgenic (Tg) and age-matched WT C57BL/6 mice. (B–E) Quantification shows the levels of HO-1, NQO1, γGCL-C, and γGCL-M in the mice brain. **p<0.01 versus WT group, ##p<0.01 versus Tg group, and $$p<0.01 versus WT+Hypo group by two-way ANOVA, n=8–10 in each group. Values represent the mean±SEM.