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. 2014 Nov 7;5:417. doi: 10.3389/fphys.2014.00417

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Copyright © 2014 Burghaus, Coboeken, Gaub, Niederalt, Sensse, Siegmund, Weiss, Mueck, Tanigawa and Lippert.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Dynamic behavior of the warfarin decay model. Graphs on the left side show the sudden onset of warfarin therapy simulated for Caucasians. Graphs on the right side show warfarin discontinuation, eventually leading to normal values for the coagulation system. Upper graphs show the values of R-warfarin and S-warfarin (arbitrary units); middle graphs show the corresponding evolution of factor concentrations; and lower graphs show coagulation time (relative to an untreated scenario) for different triggers (Table 2) in the coagulation model, depending on the factor concentrations from the middle graphs. PK, pharmacokinetics; PT, prothrombin time; TF, tissue factor; t_½, half-life.