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. 2014 Nov 7;6:306. doi: 10.3389/fnagi.2014.00306

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Copyright © 2014 Fujishima, Maikusa, Nakamura, Nakatsuka, Matsuda and Meguro.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Association between cerebral cortical thickness and white matter hyperintensity volume as a percentage of the total intracranial volume in participants with MCI. Cortical maps of regression coefficients (unstandardized beta values) and FWE-corrected p-values. The regression coefficients represent the estimated contribution to cerebral cortical thickness as millimeters per unit increase in WMH volume as a percentage of total intracranial volume. These results are overlaid on the skull-stripped study-specific template, adjusted for effects of age, gender, and years of education.