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. 2014 Nov 7;8:134. doi: 10.3389/fncir.2014.00134

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Copyright © 2014 Gozal, O'Neill, Sawchuk, Zhu, Halder, Chou and Hochman.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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OCT/PMAT transport inhibitors depress or block tryptamine and tyramine-induced LLA. Shown are simultaneous recordings from littermates in the same chamber. (A_a) Pentamidine (200 μM) depressed tryptamine-induced LLA. (A_b) Following wash, tyramine-induced LLA was also depressed by pentamidine. In both (A_a,A_b), LLA re-emerged with subsequent addition of 5-HT (not shown). (B) Time course of pentamidine-induced depression of tyramine and tryptamine-induced LLA in the same animal. LLA re-emerges after application of 5-HT (50 μM). Arrows denote time of pentamidine and 5-HT applications. R-L2 and l-L2 recordings at right present epochs with a shorter time scale for the periods highlighted by numbered green bars. Scale bars are 10 s unless otherwise shown.