Figure 7.

Similarities and differences in motor burst phenotypes observed with the monoamines and TAs. Four characteristic categories (A–D) describe the range bursting patterns observed. Frequencies varied depending on the type of bursting. (A) In the neonatal rat, 5-HT/NMDA-induced LLA has a characteristic frequency range, which was also seen when NMDA was co-applied with the other amines. (B) Dopamine and tyramine also produced a much slower rhythm, but with the same flexor-extensor left-right locomotor-like coordination. (C) NA and tyramine could also produce a much slower rhythm, but without locomotor-like coordination. (D) Seen only with the TAs, this episodic pattern is described as “Bouts of LLA superimposed on slow frequency burst episodes.” LLA and the slower episodic bursts are represented as overlapping bars in this grouping. The frequencies of slow LLA (B), slow non-LLA rhythmic bursting (C), and the slow frequency of episodic bursting (D) were statistically slower than LLA. Asterisks (^*) denote inclusion of an animal for tyramine in two categories as both behaviors emerged at different times.