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Single-strand annealing. Repair of a DSB flanked by direct repeat sequences (boxes) can occur by single-strand annealing (SSA), if 5′ to 3′ resection is allowed to progress past the repeats. The complementary single-stranded repeats can anneal, leaving heterologous flaps to be removed by the Rad1–Rad10 endonuclease, before gap-filling and ligation completes the repair thereby deleting one of the repeats and the intervening sequence.
