Table 3.

Selected results from gene set enrichment analyses performed using DAVID Bioinformatics on differentially expressed genes enriched in surface glia (SG) relative to brain (B), neurons (N), and all glia (AG).

Enriched term	Category	SG/B		SG/N		SG/AG
		N	P (adj)	N	P (adj)	N	P (adj)
DRUG METABOLISM
dme00040:Pentose and glucuronate interconversions	KEGG pathway			12	4.6E-02
dme00980:Metabolism of xenobiotics by cytochrome P450	KEGG pathway			20	1.6E-03
GO:0004364 glutathione transferase activity	GO MF			11	3.2E-02
CELL ADHESION MOLECULES
GO:0005912 adherens junction	GO CC	14	1.1E-04	14	1.1E-03
GO:0007155 cell adhesion	GO BP	22	2.8E-02	30	8.5E-04	21	4.5E-03
TRANSPORTERS
GO:0015293 symporter activity	GO MF	16	2.4E-02	19	8.4E-03	14	1.4E-02
GO:0015849 organic acid transport	GO BP			12	4.7E-02
IPR001140:ABC transporter, transmembrane region	Interpro domain	8	5.0E-02
IPR011701:Major facilitator superfamily MFS-1	Interpro domain	20	1.6E-02	21	2.8E-02	16	1.9E-02
Transport	SP_PIR keyword			49	1.0E-02	31	1.8E-02
BASEMENT MEMBRANE/ECM
GO:0005605 basal lamina	GO CC	5	1.4E-03	5	3.3E-03
GO:0031012 extracellular matrix	GO CC	18	5.5E-07	19	2.4E-06	11	4.1E-03
METABOLISM
dme00071:Fatty acid metabolism	KEGG pathway	11	1.2E-02	14	2.3E-03	9	2.2E-02
GO:0016052 carbohydrate catabolic process	GO BP			23	4.1E-06
MISCELLANEOUS
GO:0001666 response to hypoxia	GO BP	7	3.0E-02
GO:0005811 lipid particle	GO CC	39	6.2E-06	73	2.4E-21	23	1.9E-02
GO:0006952 defense response	GO BP	22	2.8E-02	26	2.3E-02
GO:0022626 cytosolic ribosome	GO CC			31	1.2E-09
GO:0045185 maintenance of protein location	GO BP	12	1.5E-03
IPR015897:CHK kinase-like	Interpro domain			14	3.7E-02	10	4.2E-02
PIRSF036514:alpha-crystallin-related small heat shock protein	PIR superfamily	6	6.7E-03

GO MF, Gene ontology molecular function; BP, biological process; and CC, cellular component. P-values are Benjamini-adjusted.