Table 6.
Selected results from gene set enrichment analyses performed using DAVID Bioinformatics on differentially expressed genes enriched in brain (B), neurons (N), and all glia (AG) relative to surface glia (SG).
| Enriched term | Category | SG/B | SG/N | SG/AG | |||
|---|---|---|---|---|---|---|---|
| N | P (adj) | N | P (adj) | N | P (adj) | ||
| GO:0001505 regulation of neurotransmitter levels | GO BP | 55 | 8.0E-07 | 32 | 2.2E-02 | ||
| GO:0007268 synaptic transmission | GO BP | 90 | 6.7E-10 | 61 | 3.8E-06 | ||
| GO:0007409 axonogenesis | GO BP | 80 | 1.3E-05 | 76 | 9.1E-12 | 17 | 1.4E-02 |
| GO:0007411 axon guidance | GO BP | 58 | 8.4E-05 | 57 | 2.2E-10 | 13 | 2.8E-02 |
| GO:0007610 behavior | GO BP | 129 | 2.5E-02 | 106 | 1.1E-04 | ||
| GO:0007611 learning or memory | GO BP | 32 | 2.4E-02 | 26 | 8.0E-03 | ||
| GO:0008038 neuron recognition | GO BP | 23 | 1.1E-04 | ||||
| GO:0008355 olfactory learning | GO BP | 18 | 2.2E-02 | ||||
| GO:0016192 vesicle-mediated transport | GO BP | 136 | 1.8E-05 | 85 | 4.2E-02 | ||
| GO:0016319 mushroom body development | GO BP | 20 | 5.2E-03 | ||||
| GO:0019933 cAMP-mediated signaling | GO BP | 11 | 3.3E-02 | 11 | 1.6E-03 | ||
| GO:0030594 neurotransmitter receptor activity | GO MF | 32 | 3.7E-02 | 29 | 3.9E-04 | ||
| GO:0031644 regulation of neurological system process | GO BP | 9 | 2.4E-02 | ||||
| GO:0034702 ion channel complex | GO CC | 27 | 5.3E-03 | 26 | 6.2E-06 | 9 | 1.0E-02 |
| GO:0045202 synapse | GO CC | 65 | 6.4E-08 | 53 | 3.7E-09 | ||
| GO:0048512 circadian behavior | GO BP | 22 | 1.5E-03 | 17 | 4.3E-03 | ||
| GO:0048666 neuron development | GO BP | 131 | 2.9E-07 | 114 | 1.0E-12 | 26 | 2.9E-03 |
GO BP, Gene ontology biological process; MF, molecular function; and CC, cellular component. P-values are Benjamini-adjusted.