Table 7.
Fly genes homologous to known junctional components expressed at the mouse BBB.
| Mouse prot | No. exp. | Best hit | E | SG exp. | SG/B | SG/N | No. enr. | Fly prot | E | SG exp. | SG/B | SG/N |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Adherens junctions | ||||||||||||
| CDH5 (VE-cadherin) | 4 | CADN | 2.E-44 | 1863 | −2.4 | 0 | ||||||
| CTNNA1 (α-catenin) | 3 | α-CAT | 0 | 924 | −3.7 | 1 | VINC | 4.E-13 | 2475 | 11.8 | 29.9 | |
| CTNNB1 (β-catenin) | 1 | ARM | 0 | 3511 | −1.9 | 0 | ||||||
| JUP (γ-catenin) | 1 | ARM | 0 | 3511 | −1.9 | 0 | ||||||
| PECAM1 | 1 | CG42330 | 1.E-07 | 518 | −4.9 | −1.9 | 0 | |||||
| Tight junctions | ||||||||||||
| CASK | 37 | CASK | 0 | 2260 | −2.5 | −2.3 | 5 | FOR | 2.E-21 | 697 | 10.9 | 77.9 |
| Unc-89 | 1.E-29 | 952 | 22.5 | 20.6 | ||||||||
| PHKγ | 3.E-50 | 1931 | −2.8 | 2.3 | ||||||||
| Lk6 | 3.E-35 | 1352 | −2.3 | 2.2 | ||||||||
| Par-1 | 1.E-37 | 1182 | −2.2 | 1.7 | ||||||||
| CGNL1 (JACOP) | 1 | ZIP | 6.E-21 | 2240 | 0 | |||||||
| ESAM | 1 | CG42368 | 4.E-06 | 271 | 0 | |||||||
| F11R (JAM-A) | 11 | ROBO | 1.E-10 | 901 | −6.1 | 4 | PPN | 7.E-06 | 3397 | 35.7 | 366.7 | |
| CG7981 | 7.E-06 | 8162 | 34.5 | 37.4 | ||||||||
| FAS2 | 6.E-07 | 4442 | 20.3 | 11.6 | ||||||||
| NRG | 4.E-07 | 2645 | 5.6 | |||||||||
| MAGI1 | 15 | Magi | 4.E-92 | 297 | 2 | CG33967 | 3.E-17 | 997 | 2.3 | 6.3 | ||
| GRIP | 2.E-09 | 325 | 10.0 | 4.5 | ||||||||
| MARVELD2 (TRIC) | 1 | Su(Tpl) | 4.E-11 | 1811 | 0 | |||||||
| MPDZ (MUPP1) | 11 | Patj | 2.E-68 | 810 | 1 | PYD | 2.E-07 | 3927 | 5.6 | −6.9 | ||
| TJP1 (ZO1) | 3 | PYD | 6.E-94 | 3927 | 5.6 | −6.9 | 1 | PYD | 6.E-94 | 3927 | 5.6 | −6.9 |
| TJP2 (ZO2) | 4 | PYD | 2.E-92 | 3927 | 5.6 | −6.9 | 1 | PYD | 2.E-92 | 3927 | 5.6 | −6.9 |
The left side of the table lists the number of homologs expressed in the surface glia (SG) followed by the best BLAST hit and its SG expression and enrichments relative to brain (B) and neurons (N). The right side lists all homologs enriched in the surface glia. No significant BLAST hits for Cldn5, Cldn12, Cldn3, Ocln, Igsf5, Pmp22, and Lsr.