Table 8.
Fly genes homologous to known transporters expressed at the mouse BBB (for notes on table format, see Table 7).
| Mouse prot | No. exp. | Best hit | E | SG exp. | SG/B | SG/N | No. enr. | Fly prot | E | SG exp. | SG/B | SG/N |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Abcb1a (Mdr1a/Pgp) | 4 | MDR49 | 0 | 1485 | 12.5 | 33.7 | 3 | Mdr65 | 0 | 6078 | 7.6 | 298.7 |
| CG10226 | 0 | 3133 | 7.9 | 85.5 | ||||||||
| MDR49 | 0 | 1485 | 12.5 | 33.7 | ||||||||
| Abcc1 (Mrp1)* | 4 | CG5789 | 0 | 218 | 5.7 | 17.1 | 4 | CG5789 | 0 | 218 | 5.7 | 17.1 |
| SUR | 2.E-54 | 111 | 5.2 | 4.3 | ||||||||
| CG11897 | 0 | 2090 | 5.0 | 2.8 | ||||||||
| MRP | 0 | 2618 | 3.1 | |||||||||
| Abcc5 (Mrp5)** | 4 | MRP | 0 | 2618 | 3.1 | 4 | CG5789 | 1.E-166 | 218 | 5.7 | 17.1 | |
| SUR | 7.E-52 | 111 | 5.2 | 4.3 | ||||||||
| CG11897 | 1.E-180 | 2090 | 5.0 | 2.8 | ||||||||
| MRP | 0 | 2618 | 3.1 | |||||||||
| Abcg2 (Bcrp) | 6 | W | 2.E-76 | 171 | 9.9 | −2.2 | 3 | CG31689 | 5.E-52 | 184 | 2.3 | 8.8 |
| CG3164 | 1.E-51 | 610 | 5.2 | |||||||||
| W | 2.E-76 | 171 | 9.9 | −2.2 | ||||||||
| Atp1a2 | 8 | ATPα | 0 | 15084 | 2 | CG42321 | 4.E-11 | 6251 | 1.5 | |||
| CG31729 | 2.E-06 | 1040 | 2.2 | |||||||||
| Lrp1 | 13 | CG8909 | 0 | 450 | −19.2 | −5.4 | 8 | LPR1 | 1.E-143 | 3632 | 15.2 | 43.2 |
| CG7981 | 1.E-44 | 8162 | 34.5 | 37.4 | ||||||||
| SLOW | 3.E-06 | 769 | 12.8 | 27.1 | ||||||||
| SHF | 1.E-14 | 1102 | 7.6 | 13.6 | ||||||||
| Dl | 5.E-11 | 299 | 4.7 | 12.1 | ||||||||
| N | 1.E-14 | 362 | 4.7 | |||||||||
| MGL | 0 | 1900 | 2.0 | 1.9 | ||||||||
| CUE | 1.E-23 | 2734 | 2.3 | |||||||||
| Slc1a1 (EAAT3)*** | 2 | EAAT1 | 2.E-92 | 2260 | 0 | |||||||
| Slc1a2 (Eaat2) | 2 | EAAT2 | 2.E-90 | 820 | −5.9 | −4.9 | 0 | |||||
| Slc2a1 (Glut1) | 8 | GLUT1 | 1.E-124 | 711 | −3.6 | −4.0 | 6 | CG3168 | 6.E-09 | 4663 | 4.2 | 241.1 |
| CG4797 | 2.E-15 | 5031 | 32.6 | 116.1 | ||||||||
| CG4607 | 4.E-25 | 1021 | 16.6 | 59.3 | ||||||||
| CG30035 | 1.E-28 | 6887 | 8.1 | 54.2 | ||||||||
| CG6231 | 2.E-08 | 1911 | 23.1 | 23.8 | ||||||||
| ORCT | 1.E-05 | 428 | 2.2 | 11.2 | ||||||||
| Slc4a2 | 2 | CG8177 | 0 | 4468 | 0 | |||||||
| Slc7a1 (Cat1) | 5 | CG13248 | 1.E-111 | 370 | 2 | Jhl-21 | 6.E-07 | 1628 | 9.9 | |||
| CG9413 | 2.E-06 | 4326 | 2.1 | 2.7 | ||||||||
| Slc7a3 (Cat3) | 1 | CG13248 | 1.E-101 | 370 | 0 | |||||||
| Slc7a5 (LAT1) | 5 | JhI-21 | 1.E-115 | 1628 | 9.9 | 2 | Jhl-21 | 1.E-115 | 1628 | 9.9 | ||
| CG9413 | 7.E-82 | 4326 | 2.1 | 2.7 | ||||||||
| Slc9a1 (Nhe1) | 2 | NHE1 | 1.E-45 | 132 | −2.2 | 0 | ||||||
| Slc16a1 (MCT1) | 6 | CG3409 | 1.E-29 | 1177 | −2.4 | 3 | CG8051 | 4.E-09 | 1472 | 117.3 | 147.8 | |
| KAR | 2.E-15 | 3132 | 13.7 | 9.4 | ||||||||
| CG13907 | 2.E-24 | 4225 | 3.8 | 3.9 | ||||||||
| Slc19a1 (RFC1) | 1 | CG6574 | 1.E-51 | 253 | 2.6 | 2.8 | 1 | CG6574 | 1.E-51 | 253 | 2.6 | 2.8 |
| Slc22a8 (OAT3) | 6 | ORCT | 1.E-60 | 428 | 2.2 | 11.2 | 6 | CG6126 | 4.E-58 | 5224 | 33.1 | 275.4 |
| CG3168 | 5.E-15 | 4663 | 4.2 | 241.1 | ||||||||
| CG6231 | 1.E-26 | 1911 | 23.1 | 23.8 | ||||||||
| ORCT2 | 2.E-57 | 1166 | 18.2 | 12.4 | ||||||||
| CG4630 | 1.E-46 | 651 | 8.3 | 12.2 | ||||||||
| ORCT | 1.E-60 | 428 | 2.2 | 11.2 | ||||||||
| Slc38a1 (SNAT1)**** | 1 | CG13743 | 7.E-15 | 291 | −9.5 | −8.6 | 0 | |||||
| Slc39a10 | 4 | FOI | 5.E-63 | 1643 | 2.4 | 1.8 | 2 | CATSUP | 1.E-20 | 430 | 2.6 | 2.6 |
| FOI | 5.E-63 | 1643 | 2.4 | 1.8 | ||||||||
| Slco1c1 (OATP-F)***** | 1 | OATP74D | 1.E-63 | 2041 | 21.4 | 64.0 | 1 | Oatp74D | 1.E-63 | 2041 | 21.4 | 64.0 |
Significant BLAST hits that are not expressed in surface glia: Slc19a2, Slc19a3, Slc30a1, and Tfrc.
*
Nearly identical results for Abcc4 (Mrp4);
**
Nearly identical results for Abcc6 (Mrp6);
***
Nearly identical results for Slc1a3 (Eaat1);
****
Nearly identical results for Slc38a3 (SNAT3) and Slc38a5 (SNAT5);
*****
Nearly identical results for Slco1a4 (Oatp2) and Slco2b1 (OATP-B).