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Homology model of MCT8. a The model is based on the structure of the bacterial glycerol-3-phosphate transporter GlpT. TMH1 is violet and TMH12 is red. In the top view, i.e. from the extracellular side, a central channel is apparent which is closed on the extracellular side. b Missense and small indel mutations mapped on the homology model of MCT8. P321L is located at the interface of the two 6-helix bundles and G401R marks a sharp kink between the horizontal helix and TMH7.
