Figure 6.

MVPA classification based on thalamo-cortical dysconnectivity. (A) As in Figure 1, schizophrenia (SCZ) results used to train the classifier. (B) Discovery sample results showing above-chance classification accuracy. (C) Between-group map for the SCZ replication sample (N = 23), shown unthresholded, masked with regions from panel A (to allow inspection relative to original findings). Red and blue borders mark whole-brain corrected increased and decreased thalamic connectivity, respectively, identified in the original SCZ sample. (D) SCZ replication classification. (E) Between-group difference map for bipolar patients (N = 67), again shown unthresholded, masked with panel A regions and surrounded by borders. (F) Bipolar disorder (BP) and control (CON) classification. For comprehensive visualization of volume-based type I error corrected group differences and unthresholded surface group contrast maps across samples, see Supplementary Figs 1, 2, and 4. Of note, sensitivity and specificity were 75.5 and 72.2, respectively, for the discovery sample and 67.9 and 77.8 for the replication sample.