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. Author manuscript; available in PMC: 2015 Jan 1.
Published in final edited form as: RSC Adv. 2014 Oct 10;4(96):54051–54059. doi: 10.1039/C4RA10749G

Table 2.

Michael addition with different substrates and at large scales

Trial Substrate Conditions ee (%) HPLC yield (%)
54 1a Small scale, 15 µmol 1a, 0.4 M glycerol >99 (−) 96
69 1b Small scale, 15 µmol 1b, 0.4 M glycerol 98.4 40
70 1c Small scale, 15 µmol 1c, 0.4 M glycerol 96.8 27
71 1d Small scale, 15 µmol 1d, 0.4 M glycerol >99 85
72 1d Small scale, 15 µmol 1d, 0.2 M [BMIM][CF3COO] >99 95
73 1e Small scale, 15 µmol 1e, 0.4 M glycerol 97.0 77
74 1f Small scale, 15 µmol 1f, 0.4 M glycerol >99 49
75 1a Large scale, 0.3 mmol 1a (× 20 times), 0.4 M glycerol >99 (−) 93
76 1a Large scale, 0.94 mmol 1a (× 63 times), 0.4 M glycerol >99 (−) 60
77 1a Large scale, 2.4 mmol 1a (× 160 times), 0.4 M glycerol >99 (−) 20