Table 3.

Increases in C-Statistic for Prediction of Pump Failure and Sudden Cardiac Death with Incremental Addition of Biomarkers

Prediction Models	Pump Failure C-Statistic	Sudden Cardiac Death C-Statistic
Clinical Model*	0.82 (0.73–0.91)	0.68 (0.58–0.78)
NT-proBNP univariate	0.83 (0.74–0.91)	0.67 (0.58–0.76)
Galectin-3 univariate	0.76 (0.67–0.84)	0.66 (0.57–0.75)
ST2 univariate	0.79 (0.70–0.88)	0.64 (0.55–0.73)
Clinical Model * + NT-proBNP	0.87 (0.78–0.96)	0.73 (0.64–0.83)
Clinical Model * + Galectin-3	0.83 (0.74–0.92)	0.71 (0.62–0.81)
Clinical Model* + ST2	0.86 (0.77–0.95)	0.72 (0.62–0.82)
Clinical Model* + NT-proBNP + Galectin-3	0.88 (0.79–0.97)	0.74 (0.64–0.84)
Clinical Model* + NT-proBNP + ST2	0.88 (0.79–0.96)	0.75 (0.65–0.85)
Clinical Model* + NT-proBNP + ST2 + Galectin-3	0.89 (0.80–0.98)	0.75 (0.65–0.85)

^*HF-ACTION Clinical Adjustment Model: Serum creatinine level, Body Mass Index, Sex, Dosage of loop diuretic, Left Ventricular ejection fraction, CCS angina classification, and resting ECG Ventricular Conduction abnormality. NT-proBNP indicates amino-terminal proB-type natriuretic peptide.