Table 4.

Enriched GO Terms Identified based on K_a/K_s Sorting in both RNA-Seq Libraries for Fast-Evolving Genes in Cephalochordate Evolution

GO ID	Term	Category	FDR
			asymAD	asym20h
GO:0031012	Extracellular matrix	C	4.38 × 10−5	2.45 × 10−5
GO:0004872	Receptor activity	F	1.02 × 10−4	2.45 × 10−5
GO:0048495	Roundabout binding	F	1.02 × 10−4	1.10 × 10−3
GO:0050919	Negative chemotaxis	P	1.02 × 10−4	1.18 × 10−4
GO:0021834	Chemorepulsion involved in embryonic olfactory bulb interneuron precursor migration	P	1.53 × 10−4	1.10 × 10−3
GO:0035385	Roundabout signaling pathway	P	1.53 × 10−4	1.99 × 10−3
GO:0051414	Response to cortisol stimulus	P	1.53 × 10−4	1.10 × 10−3
GO:0061364	Apoptotic process involved in luteolysis	P	1.53 × 10−4	1.99 × 10−3
GO:0070100	Negative regulation of chemokine-mediated signaling pathway	P	1.53 × 10−4	1.99 × 10−3
GO:0007155	Cell adhesion	P	3.84 × 10−4	8.51 × 10−4
GO:0005576	Extracellular region	C	5.91 × 10−4	1.13 × 10−10
GO:0002689	Negative regulation of leukocyte chemotaxis	P	6.73 × 10−4	1.00 × 10−4
GO:0005578	Proteinaceous extracellular matrix	C	1.07 × 10−3	7.80 × 10−3
GO:0050922	Negative regulation of chemotaxis	P	1.15 × 10−3	3.58 × 10−3
GO:0048846	Axon extension involved in axon guidance	P	1.72 × 10−3	3.22 × 10−2
GO:0044421	Extracellular region part	C	4.46 × 10−3	2.44 × 10−8
GO:0021772	Olfactory bulb development	P	6.56 × 10−3	8.90 × 10−3
GO:0004888	Transmembrane signaling receptor activity	F	1.16 × 10−2	1.98 × 10−2
GO:0086070	SA node cell to atrial cardiac muscle cell communication	P	4.02 × 10−2	2.55 × 10−2

Note.—For the GO term category column, “C” stands for cellular component, “F” for biological function, and “P” for biological process. The statistical significance was assessed by Fisher’s exact test with FDR correction.

FDR = false discover rate.