Table 4.
Expected and Observed Numbers of Breast Cancer Cases Under Additive and Multiplicative Joint-Effects Model Assumptions in the Breast and Prostate Cancer Cohort Consortium
| No. of Risk Alleles | No. of Cases Expected (Additive Model) | No. of Cases Observed | No. of Cases Expected (Multiplicative Model) |
|---|---|---|---|
| ≤10 | 15.5 | 11 | 9.3 |
| 11 | 30.4 | 28 | 19.8 |
| 12 | 73.5 | 67 | 50.9 |
| 13 | 152.4 | 124 | 111.5 |
| 14 | 329.7 | 268 | 255.9 |
| 15 | 559.0 | 495 | 460.1 |
| 16 | 873.3 | 796 | 757.9 |
| 17 | 1,158.8 | 1,085 | 1,061.0 |
| 18 | 1,382.9 | 1,354 | 1,328.8 |
| 19 | 1,398.8 | 1,414 | 1,412.0 |
| 20 | 1,298.5 | 1,340 | 1,369.5 |
| 21 | 1,087.7 | 1,132 | 1,196.1 |
| 22 | 808.5 | 896 | 924.0 |
| 23 | 480.3 | 561 | 569.2 |
| 24 | 275.9 | 299 | 337.1 |
| 25 | 126.5 | 161 | 159.9 |
| 26 | 58.8 | 69 | 75.4 |
| 27 | 24.7 | 32 | 33.0 |
| ≥28 | 10.8 | 14 | 14.7 |