Figure 2. MTCM estimates time-activity curves in multiple vascular compartments simultaneously and quantitatively reconstructs tissue-specific local volume transfer constants - synthetic DCE-MRI experiments: (a) synthesis of image series; (b) scatter simplex of synthesized image series; (c) tissue-specific compartmental tracer concentration curves and local volume transfer constant maps, estimated by MTCM; (d) MDL model selection to detect the number of compartments; (e) tissue-specific compartmental tracer concentration curves estimated by principle component analysis (PCA).