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. 2014 Nov 7;9(11):e112250. doi: 10.1371/journal.pone.0112250

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© 2014 Hugosson et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Loss of Miple proteins affect lifespan. Decreased mean lifespan is observed in miple1^Δ194/Df(3L)BSC125 (open circles) and miple2^Δ396/Df(3L)BSC125 (filled triangles) single mutant flies as well as miple1,miple2^Δ104/Df(3L)BSC125 (open triangles) double mutants. Revertant control^rev ⁶⁵⁷ /Df(3L)BSC125 (filled circles) were employed as control (B) Ectopic over-expression of both Miple1 (open circles) and Miple2 (filled triangles) with actin5C-Gal4 increases mean lifespan in comparison to controls (filled circles). All analysed flies were females. Number of flies is indicated as n. (C-F) miple1 mRNA is strongly expressed in adult brain. No expression of miple1 mRNA is detected in miple1,miple2^Δ104 double mutant brains (E). miple2 mRNA in situ in adult brains. No miple2 mRNA expression is detected in either wildtype (D) or miple1,miple2^Δ104 double mutant control brains (F).