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Mechanism of binding for (a) G5-(COG-FA) conjugates to FBP mimics slow, tight binding. (b) G5-(COG-MTX) conjugates cause less protein conformational change to the polymer and do not irreversibly bind. (c) D-(COG-MTX) conjugates also demonstrate slow, tight binding. Abbreviations: COG = cyclooct-1-yn-3-glycolic acid, C = polymer conjugate, P = protein.
