Table 1. Summary of Isolated, Precise Ratio Cycloalkyne/Dendrimer Conjugates.
| vector | ligand | target valency | UPLC average | UPLC purity |
|---|---|---|---|---|
| monomer | COG | 0 | 0.0 | 100% |
| monomer | COG | 1 | 1.1 | 100% |
| monomer | COG | 2 | 1.9 | 90% |
| monomer | COG | 3 | 2.8 | 93% |
| dimer | COG | 0 | 0.0 | 100% |
| dimer | COG | 1 | 1.1 | 91% |
| dimer | COG | 2 | 2.0 | 100% |
| dimer | COG | 3+ | 6.2 | n/a |
| monomer | MFCO | 0 | 0.0 | 100% |
| monomer | MFCO | 1 | 1.0 | 100% |
| monomer | MFCO | 2 | 1.9 | 91% |
| monomer | MFCO | 3 | 3.0 | 99% |
| monomer | MFCO | 4+ | 6.6 | n/a |
| dimer | MFCO | 0 | 0.0 | 100% |
| dimer | MFCO | 1 | 1.1 | 100% |
| dimer | MFCO | 2 | 2.1 | 100% |
| dimer | MFCO | 3+ | 5.3 | n/a |