Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2014 Aug 28;18(11):2213–2224. doi: 10.1111/jcmm.12353

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2014 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Schematic diagram showing the hypothetical role of miR-21 in rheumatoid arthritis (RA) patients. In the normal setting, miR-21 can inhibit inflammation by positively regulating Treg cell development or negatively regulating STAT3. However, decreased levels of miR-21 may increase the expression and activation of STAT3, and simultaneously reduce the expression and activation of STAT5, promoting the Th17 cell differentiation while suppressing Treg cell development during chronic inflammation in RA.